Effects of morphine-treated fetal mice on spatial learning after birth
| Author | M H Esmaeili | en |
| Author | M Sofiabady | en |
| Author | F Rajaei | en |
| Author | H Jahany Hashemy | en |
| Issued Date | 2008-03-31 | en |
| Abstract | Abstract Background: Drug abuse during pregnancy is a growing problem in all developed countries worldwide. Maternal drug abuse affects the developing systems and the associated long-term effects can persist untill adulthood, decreasing the rate of their maturation. Objective: To determine the effects of prenatal morphine exposure on spatial learning Methods: Eighteen pregnant rats were divided into morphine, saline, and control groups. Morphine or saline was administrated (S.C) to female rats twice a day (at 12-hr intervals) during the days 11-18 of their gestational period (5 mg/kg morphine for the first 3 days and 10 mg/kg for further 5 days). Pups (P90, n=6) were trained in an 8-arm radial maze apparatus.The data were analyzed statistically using Chi-square test. Findings: The results indicated that prenatal morphine exposure causes a reduction in the time needed to learn these trials however, they needed more time to complete regular trials. Conclusion: Prenatal morphine exposure impairs normal spatial learning. | en |
| DOI | https://doi.org/ | en |
| Keyword | Keywords: Morphine | en |
| Keyword | Fetus | en |
| Keyword | Narcotics | en |
| Keyword | Learning | en |
| Keyword | Pregnancy | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Effects of morphine-treated fetal mice on spatial learning after birth | en |
| Type | Research Article | en |
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