Evaluation of Salivary Endothelin1 Level in Patients with Oral Lichen Planus
| Author | Maryam Robati | en |
| Author | Hojatollah Yousefimanesh | en |
| Author | Zahra Zarei | en |
| Author | Ataollah Ghadirpur | en |
| Orcid | Hojatollah Yousefimanesh [0000-0003-0844-2295] | en |
| Issued Date | 2018-02-28 | en |
| Abstract | Background: Oral lichen planus (OLP) is a chronic inflammatory disease with muco - cutaneous involvement and unknown etiology. Endothelin1 (ET - 1) is a potent vasoconstrictor peptide, which is associated with some inflammatory diseases. The present study aimed at measuring and comparing the salivary level of ET - 1 in patients with OLP. Methods: The current case - control study included 20 Iranian patients diagnosed with OLP as the case and 20 age - sex - matched healthy volunteers as the control groups. All the participants signed the informed consent form before recruitment. The ET - 1 level in whole unstimulated saliva (WUS) was determined by the enzyme - linked immunosorbent assay (ELISA) technique. Statistical analysis was conducted using ANOVA and t test. Results: The mean salivary ET - 1 level in patients with OLP showed no significant difference compared with that of the control group (24.67 ± 12.07 pg/mL vs. 26.83 ± 7.73 pg/mL; P > 0.05). There were no significant difference in the salivary ET - 1 level between the reticular and erythematous - erosive groups (23.31 ± 9.12 pg/mL vs. 25.78 ± 13.99 pg/mL; P > 0.05). Conclusions: There were no significant differences in terms of the salivary ET - 1 level between the OLP and control groups. | en |
| DOI | https://doi.org/10.5812/jjhr.12025 | en |
| Keyword | Oral | en |
| Keyword | Lichen Planus | en |
| Keyword | Saliva | en |
| Keyword | Endothelin 1 | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Salivary Endothelin1 Level in Patients with Oral Lichen Planus | en |
| Type | Research Article | en |
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