A Computational Study of Some Benzenesulfonamide Derivatives as HIV- 1 Protease Enzyme Inhibitors: Three-Dimensional Quantitative Structure-Activity Relationship and Molecular Docking

Abstract

Background: The prevalence of human immunodeficiency virus 1 (HIV-1) infection remains a global concern due to the lack of a definitive treatment. Human immunodeficiency virus 1 protease is a homodimeric aspartic protease enzyme essential in the maturation process of HIV protein and could be a promising target for treating retrovirus infections.