Alteration Effect of Exendin-4 on Oxidative Stress and Metabolic Disorders Induced by Bisphenol A in Adult Male Mice

Abstract

Background: Exendin-4 is a similar peptide to GLP-1 and can interfere with various receptors of GLP-1. Bisphenol A (BPA), as an endocrine disruptor chemical, is used in a wide range of plastic products. Objectives: The aim of this study was to clarify several exendin-4 aspects in treatment of metabolic disorders. Methods: In in vivo condition, the BPA (100 µg/kg) and exendin-4 (4 nmol/kg/d) were administered for 20 days in four different groups, and blood glucose, insulin, lipid profile, adipocyte hormones and oxidative stress markers were examined. Results: The results indicate that co-administration of exendin-4 and BPA modified hyperglycemia and hyperlipidemia induced by BPA. Bisphenol A reduced antioxidant level, whereas exendin-4 improved these effects. Conclusions: The findings of these studies suggest that the use of exendin-4 is useful in hyperglycemia, hyperlipidemia and metabolic disorders, induced by BPA.