Alteration Effect of Exendin-4 on Oxidative Stress and Metabolic Disorders Induced by Bisphenol A in Adult Male Mice
| Author | Akram Ahangarpour | en |
| Author | Golshan Afshari | en |
| Author | Seyyed Ali Mard | en |
| Author | Ali Khodadadi | en |
| Author | Mahmoud Hashemitabar | en |
| Issued Date | 2016-10-01 | en |
| Abstract | Background: Exendin-4 is a similar peptide to GLP-1 and can interfere with various receptors of GLP-1. Bisphenol A (BPA), as an endocrine disruptor chemical, is used in a wide range of plastic products. Objectives: The aim of this study was to clarify several exendin-4 aspects in treatment of metabolic disorders. Methods: In in vivo condition, the BPA (100 µg/kg) and exendin-4 (4 nmol/kg/d) were administered for 20 days in four different groups, and blood glucose, insulin, lipid profile, adipocyte hormones and oxidative stress markers were examined. Results: The results indicate that co-administration of exendin-4 and BPA modified hyperglycemia and hyperlipidemia induced by BPA. Bisphenol A reduced antioxidant level, whereas exendin-4 improved these effects. Conclusions: The findings of these studies suggest that the use of exendin-4 is useful in hyperglycemia, hyperlipidemia and metabolic disorders, induced by BPA. | en |
| DOI | https://doi.org/10.17795/jjhr-37836 | en |
| Keyword | Bisphenol A | en |
| Keyword | Exendin-4 | en |
| Keyword | Leptin | en |
| Keyword | Adiponectin | en |
| Keyword | Oxidative Stress | en |
| Keyword | Lipid Profile | en |
| Publisher | Brieflands | en |
| Title | Alteration Effect of Exendin-4 on Oxidative Stress and Metabolic Disorders Induced by Bisphenol A in Adult Male Mice | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 21932-pdf.pdf
- Size:
- 269.95 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF