Effects of Aqueous Extract of Purslane <i>(Portulaca oleracea)</i> on Hepatic Enzymes in Two Models of Renal Ischemia-Reperfusion Injury in Rats

Abstract

Objectives: This study investigated the effect of purslane on hepatic enzymes following renal ischemia-reperfusion (IR) injury in rats by two methods. Materials and Methods: In this experimental study, 36 male Wistar rats randomly divided into 6 groups (n = 6): I) previously nephrectomized control, II) simultaneously nephrectomized control, III) previously nephrectomized + IR, IV) simultaneously nephrectomized + IR, V) previously nephrectomized treated by aqueous extract of P. oleracea L. + IR, VI) simultaneously nephrectomized treated by aqueous extract of P. oleracea L. + IR control and ischemia-reperfusion groups received vehicle and treatment groups received aqueous extract of purslane (300 mg/kg). In model 1, the right kidney was nephrectomized, 20 days prior to experiment, in model 2; nephrectomy was done just before induction of 45 minutes ischemia and 24 hours reperfusion to the left kidney. Results: Hepatic enzymes were elevated after induction of ischemia reperfusion. Administration of purslane decreased hepatic enzymes. Conclusions: Purslane prevented liver damage more effectively in simultaneously nephrectomized model.