Effects of Aqueous Extract of Purslane <i>(Portulaca oleracea)</i> on Hepatic Enzymes in Two Models of Renal Ischemia-Reperfusion Injury in Rats
| Author | Majid Askaripour | en |
| Author | S. Reza Fatemi-Tabatabaei | en |
| Author | Foruzan Hosseini | en |
| Author | Masoome Rashno | en |
| Author | Shahab Ghaderi | en |
| Issued Date | 2016-02-29 | en |
| Abstract | Objectives: This study investigated the effect of purslane on hepatic enzymes following renal ischemia-reperfusion (IR) injury in rats by two methods. Materials and Methods: In this experimental study, 36 male Wistar rats randomly divided into 6 groups (n = 6): I) previously nephrectomized control, II) simultaneously nephrectomized control, III) previously nephrectomized + IR, IV) simultaneously nephrectomized + IR, V) previously nephrectomized treated by aqueous extract of P. oleracea L. + IR, VI) simultaneously nephrectomized treated by aqueous extract of P. oleracea L. + IR control and ischemia-reperfusion groups received vehicle and treatment groups received aqueous extract of purslane (300 mg/kg). In model 1, the right kidney was nephrectomized, 20 days prior to experiment, in model 2; nephrectomy was done just before induction of 45 minutes ischemia and 24 hours reperfusion to the left kidney. Results: Hepatic enzymes were elevated after induction of ischemia reperfusion. Administration of purslane decreased hepatic enzymes. Conclusions: Purslane prevented liver damage more effectively in simultaneously nephrectomized model. | en |
| DOI | https://doi.org/10.17795/zjrms-5995 | en |
| Keyword | Hepatic Enzymes | en |
| Keyword | Oxidative Stress | en |
| Keyword | Purslane | en |
| Keyword | Remote Organ Injury | en |
| Publisher | Brieflands | en |
| Title | Effects of Aqueous Extract of Purslane <i>(Portulaca oleracea)</i> on Hepatic Enzymes in Two Models of Renal Ischemia-Reperfusion Injury in Rats | en |
| Type | Brief Report | en |
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