Resistin In Systemic Lupus Erythematosus: Correlation with Disease Activity and Inflammatory Markers

Abstract

Objectives: In recent years, there is some evidence that adipokins play an important role in autoimmunity and inflammation. Resistin is the novel adipocyte-derived peptid and the aim of this study was to compare its serum values in lupus patients and controls. Methods: A cross sectional study was carried out on 73 patients with the definite diagnosis of SLE. Resistin and other proinflammatory markers were compared between patients and normal age and sex match individuals. Results: There was no significant difference in serum resistin, concentrations, between patients and healthy individuals (6.88 ± 4.53 and 6.74 ± 3.74 ng/mL respectively, P = 0.704). Statistical analysis showed a positive correlation between serum, levels of resistin with CRP and ESR (P ≤ 0.008 and P ≤ 0.037 respectively), in SLE patients. Higher serum levels of resistin in patients with proteinuria were found in comparison with normal kidney patients (P = 0.022). But there was no relationship between resistin like SLEDAI score. Conclusions: Resistin was associated with in inflammatory markers but not a notable association with markers of disease activity has been detected.